Endocrine Abstracts

Kenneth S Korach, National Institute of Environmental Health Sciences, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA AbstractKenneth S Korach is the Program Director of the Environmental Disease and Medicine Program, Chief of the Laboratory of Reproductive and Developmental Toxicology at the National Institute of Environmental Health...

Kenneth S Korach, National Institute of Environmental Health Sciences, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA AbstractKenneth S Korach is the Program Director of the Environmental Disease and Medicine Program, Chief of the Laboratory of Reproductive and Developmental Toxicology at the National Institute of Environmental Health...

Anti-mullerian hormone (AMH), is a member of the TGFbeta family of growth and differentiation factors. Also known as mullerian inhibiting substance, AMH plays an essential role during male sex differentiation, where it signals the regression of the mullerian ducts.However, in the postnatal female AMH plays an important role in growth and development of ovarian follicles. In both rodents and women, AMH is expressed in primary follicles immediately after t...

Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women in their reproductive years, is defined by two out of the following three criteria: hyperandrogenism, oligo/anovulation, and polycystic ovaries. Affected women are often obese and insulin-resistant. Recently, we developed a mouse PCOS-model through chronic exposure to dihydrotestosterone (DHT). Here, we studied whether the PCOS-phenotype remains after withdrawal of DHT treatment, which would more clo...

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women in their reproductive age. Based on the Rotterdam criteria PCOS is defined by two out of the following three criteria: hyperandrogenism, oligo/anovulation, and polycystic ovaries. In addition, PCOS patients are often abdominal obese, which can lead to insulin resistance. The subsequent increased insulin levels stimulate the ovary to further increased androgen production. Thus, the elevated androgen...

Introduction: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders of premenopausal women. It is also the most frequent cause of female infertility and affects 6.5–8% of women in their reproductive age. Two out of three criteria diagnoses PCOS: oligo- or anovulation, clinical or biochemical signs of hyperandrogenism and polycystic ovaries at ultrasound. In addition, PCOS women frequently display features of the metabolic syndrome, such as abdomin...

Introduction: Severe hypocalcemia is a life threatening condition, usually symptomatic with cardiovascular and neuromuscular manifestations. Varying clinical presentations and concomitant infections, however, might obscure the right diagnosis, delaying early treatment.Case: A 51-year-old African male presents himself at the emergency department (ED) with complaints of a soar throat, a productive cough and a striking pinched voice. Investigation revealed ...

Anti-Mullerian hormone (AMH) is expressed in the ovary, in granulosa cells (GC) of preantral and antral follicles. Mice lacking the AMH gene show an increase in the proportion of early growing follicles and a reciprocal decrease in the primordial pool, suggesting an important role in early follicle growth. Little is known about the expression of AMH in the human ovary. Recent studies have shown that the proportion of follicles entering the growing pool is increased in PCO, sim...

Hypothyroidism causes delayed ossification and growth retardation. T3 stimulates hypertrophic chondrocyte differentiation whereas unliganded T3 receptors (TRs) repress gene expression and maintain cell proliferation in the absence of hormone. During development the type 3 deiodinase enzyme (D3) inactivates thyroid hormones and prevents T3-access to the fetus. At birth diminishing D3 activity and increasing T3 availability triggers the onset of cell differentiation and correlat...